Cell 2024 187(11):2717-2734.e33

Authors

Qixing Nie#, Xi Luo#, Kai Wang#, Yong Ding#, Shumi Jia#,…, Yanli Pang*, Jie Qiao*, Changtao Jiang*

Abstract

The microbial bile acid 3-succinylated cholic acid is biosynthesized by BAS-suc, an enzyme annotated as b-lactamase in Bacteroides uniformis, and it alleviates MASH progression by enriching the abundance of the beneficial gut bacterium Akkermansia muciniphila.

Highlight

A click-chemistry-based strategy identifies the microbial- derived bile acid 3-sucCA

B. uniformis-expressed BAS-suc is responsible for 3-sucCA biosynthesis

3-sucCA is negatively correlated with liver damage in patients with MAFLD

3-sucCA alleviates MASH in mice by promoting A. muciniphila growth