Yan Liying, Professor at Peking University Third Hospital, recipient of the National Science Fund for Distinguished Young Scholars and National Science Fund for Excellent Young Scholars. Currently serves as Deputy Director of the Department of Obstetrics and Gynecology, Director of the Research Office at Peking University Third Hospital, and Deputy Director of the State Key Laboratory of Female Fertility Promotion. Awarded the National Science Fund for Excellent Young Scholars and Distinguished Young Scholars and leads national key RESEARCH AND DEVELOPMENT projects and 863 Program initiatives. Her research focuses on embryonic development and genetic diagnosis, exploring key molecules determining early embryonic cell fate and elucidating the mechanisms by which genetic material and epigenetic modifications are transmitted to offspring through gametogenesis and embryonic development. She has developed embryo and prenatal diagnostic methods for complex variant detection and special pedigrees, successfully applied in clinical settings to help patients conceive healthy offspring. Published over 50 SCI articles as first or corresponding author (including co-authorship) in journals including Nature, Cell, Nat Genet, and Mol Cell.

(1) Standing Committee Member, Seventh Committee of the Medical Cell Biology Branch, Chinese Medical Association

(2) Standing Council Member, Eleventh Council of the Chinese Society of Genetics

(3) Member, Third Committee, Medical Geneticists Branch, Chinese Medical Doctor Association

(4) Member, Third Committee, Medical Geneticists Branch, Chinese Medical Doctor Association

(5) Member, Women Scientists Branch, Chinese Society of Genetics

(6) Vice Chairperson, Genetics Branch, Beijing Medical Association

(7) Member, Laboratory Animal Facilities and Equipment Technology Branch, China Entry-Exit Inspection and Quarantine Association

Recipient of one First Prize in Natural Science for Maternal and Child Health Science and Technology, two Second Prizes in National Science and Technology Progress, one Second Prize in National Natural Science, two First Prizes in Beijing Science and Technology Progress, Mao Yisheng Beijing Youth Science and Technology Award, selected for the Ministry of Science and Technology-Gates Foundation-Grand Challenges Young Scientist Program, research achievements selected three times for “China's Top Ten Scientific Advances” (2014/2015/2024)

(1) Key RESEARCH AND DEVELOPMENT Program of the Ministry of Science and Technology: Metabolic Patterns in Embryos and Mechanisms of Cell Fate Determination, Dec 2023–Nov 2028, Principal Investigator

(2) National Natural Science Foundation of China (NSFC) Outstanding Young Scientist Fund: Embryonic Development and Genetic Diagnosis, Jan 2022–Dec 2026, Project Leader

(3) National Natural Science Foundation of China Center for Basic Science Project, Female Reproductive Aging and Fertility Remodeling, Jan 2023–Dec 2027, Sub-project Leader

(4) Key RESEARCH AND DEVELOPMENT Program of the Ministry of Science and Technology, Regulation Networks of Preimplantation Embryonic Development, Dec 2018–Dec 2021, Principal Investigator

(5) National Natural Science Foundation of China (NSFC) Outstanding Young Scientist Fund, Mechanisms of Early Human Embryonic Development, Jan 2016–Dec 2018, Sub-project Leader

1）Guo Q#, Xu F#, Song S#, Kong S#, Zhai F#, Xiu Y, Liu D, Li M, Lian Y, Ding L, Liu Q, Yang M, Du; Z, Wang N, Long C, Wang X, Wang Y, Yan Z, Qiao J*, Yan L*, Yuan P*. Allelic transcriptomic profiling identifies the role of PRD-like homeobox genes in human embryonic-cleavage-stage arrest. Developmental Cell. 2025;60(9):1290-1303.

（2）Lu Y#, Qin M,# He Q#, Hua L#, Qi X#, Yang M, Guo Q, Liu X, Zhang Z, Xu F, Ding L, Wu Y, Zhang C, Zhai F, Liu Q, Li J, Yuan P, Shi X, Wang X, Zhao C, Lian Y, Li R, Wei Y*, Yan L*, Yuan P*, Qiao J*. How the extra X chromosome impairs the development of male fetal germ cells. Nature. 2024;635(8040):960-968.

（3）Wang Y#, Li Y#, Zhu X, Yang M, Liu Y, Wang N, Long C, Kuo Y, Lian Y, Huang J, Jia J, Wong C, Yan Z*, Yan L*, Qiao J*. Concurrent Preimplantation Genetic Testing and Competence Assessment of Human Embryos by Transcriptome Sequencing. Adv Sci. 2024; 11(32):e2309817.

（4）Zhai F#, Kong S#, Song S#, Guo Q#, Ding L, Zhang J, Wang N, Kuo Y, Guan S, Yuan P*, Yan L*, Yan Z*, Qiao J*. Human embryos harbor complex mosaicism with broad presence of aneuploid cells during early development. Cell Discov. 2024;10(1):98.

（5）An J#, Wang J#, Kong S, Song S, Chen W, Yuan P, He Q, Chen Y, Li Y, Yang Y, Wang W, Li R, Yan L*, Yan Z*, Qiao J*. GametesOmics: A Comprehensive Multi-omics Database for Exploring the Gametogenesis in Humans and Mice. Genomics, Proteomics & Bioinformatics. 2024; 22(1): qzad004.

（6）Dang Y#, Zhu L#, Yuan P#, Liu Q#, Guo Q, Chen X, Gao S, Liu X, Ji S, Yuan Y, Lian Y, Li R*, Yan L*, Wong CL*, Qiao J*. Functional profiling of stage-specific proteome and translational transition across human pre-implantation embryo development at a single-cell resolution. Cell Discov. 2023;10.

（7）Liu D#, Chen Y#, Ren Y#, Yuan P, Wang N, Liu Q, Yang C, Yan Z, Yang M, Wang J, Lian Y, Yan J, Zhai F, Nie Y, Zhu X, Chen Y, Li R, Chang HM, Leung PCK, Qiao J*, Yan L*. Primary specification of blastocyst trophectoderm by scRNA-seq: New insights into embryo implantation. Sci Adv.2022;eabj3725.

（8）Yan Z#, An J#, Peng Y, Kong S, Liu Q, Yang M, He Q, Song S, Chen Y, Chen W, Li R, Qiao J*,Yan L*. DevOmics: an integrated multi-omics database of human and mouse early embryo. Briefings in bioinformatics. 2021; 22(6): bbab208.

（9）Wang Y#, Yuan P#, Yan Z#, Yang M, Huo Y, Nie Y, Zhu X, Qiao J*, Yan L*. Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos. Nat Commun. 2021;12(1):1247.

（10）Yuan P#, Guo Q#, Guo H, Lian Y, Zhai F, Yan Z, Long C, Zhu P, Tang F, Qiao J,Yan L*. The methylome of a human polar body reflects that of its sibling oocyte and its aberrance may indicate poor embryo development. Hum Reprod. 2021;36(2):318-330.