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Faculty

Position:
English Faculty Content

Lu Yongjie

PhD, Master's Supervisor

Research Focus:
Physiological and pathological regulatory mechanisms of germ cell development.Construction of in vitro models for germ cell development.Development of interventions for germ cell development disorders.

Admission Specialties:Basic Medicine, Clinical Medicine, Biology, Bioinformatics, etc., with strong interest in reproductive development.

Address:B4015, 4th Floor, Reproductive Medicine Center, Peking University Third Hospital

Tel/Fax:13718198473

E-mail:yongjie_lu@bjmu.edu.cn

个人简介

卢永杰副研究员,北京大学第三医院生殖中心新体制副研究员。主要研究方向为生殖细胞发育的调控机制研究。主持国家自然科学基金项目。国家重点研发项目骨干。以第一作者在Nature、Human Reproduction Open、Science China Life Sciences等高水平SCI杂志发表论文,研究入选2024年“中国科学十大进展”。曾获“北京大学医学部优秀博士后”及“北京大学优秀博士后”称号。获得授权专利2项,参编专著2部。

承担项目

1. 国家重点研发项目,性腺微环境对生殖细胞发育与分化的调控,2024YFA1802100,2024.12-2029.11,87.53万元,在研,骨干

2. SOX15异常高表达导致克氏综合征胎儿生殖细胞分化障碍的机制研究,82101677,2022.1-2024.12,30万元,结题,主持

代表性论文

1. Lu Y*, Qin M*, Qi X*, Yang M, Zhai F, Zhang J, Yan Z, Yan L#, Qiao J#, Yuan P#. Sex differences in human pre-gastrulation embryos. Sci China Life Sci. 2025 Feb;68(2):397-415.

2. Lu Y*, Qin M*, He Q*, Hua L*, Qi X*, Yang M, Guo Q, Liu X, Zhang Z, Xu F, Ding L, Wu Y, Zhang C, Zhai F, Liu Q, Li J, Yuan P, Shi X, Wang X, Zhao C, Lian Y, Li R, Wei Y#., Yan L#., Yuan P#., Qiao J#. How the extra X chromosome impairs the development of male fetal germ cells. Nature. 2024 Nov;635(8040):960-968.

3. Lu Y*, Tian T*, Chen L, Yan L, Chang L#, Qiao J#. Impacts of male chromosomal polymorphisms on semen quality and IVF/ICSI outcomes: A retrospective cohort study. Int J Gynaecol Obstet. 2024 Sep;166(3):1247-1262.

4. Lu Y, Tian T, Chen L, Yan L, Chang L#, Qiao J#. Diverse impacts of female chromosomal polymorphisms on assisted reproduction outcomes: a retrospective cohort study. BMC Pregnancy Childbirth. 2024 Apr 27;24(1):331.

5. Lu YJ, Li Q, Chen LX, Tian T, Kang J, Hao YX, Zhou JS, Wang YY, Yan LY, Li R, Chang L#, Qiao J#. Association between maternal MTHFR C677T/A1298C combination polymorphisms and IVF/ICSI outcomes: a retrospective cohort study. Hum Reprod Open. 2022 Dec 5;2023(1):hoac055.

国家发明专利

1. 乔杰,闫丽盈,卢永杰,花凌月,于富海,袁鹏,秦萌,齐心童. 一种同时原位荧光检测人类 RNA、DNA、蛋白质的方法, 2024,中国,ZL202410296596.8

2. 乔杰,赵屹,田婵,罗纯龙,卢永杰,靳辉,于天琦,于富海,王曼卿,肖立. 基于深度学习的分裂中期染色体图像质量筛选方法和系统,2021,中国,ZL202110939852.7