副研究员，硕士生导师。主要从事人类早期胚胎发育的表观遗传调控，结合临床重大问题揭示配子及胚胎发育相关机制。研究成果发表在Nature、Developmental Cell等高水平SCI杂志发表。获得2项国家授权发明专利，主持国家自然科学基金项目、国家重点研发计划课题、北京市科学基金等项目。获得中国科协青年托举人才、北京市科技进步一等奖等。研究成果入选2024年度“中国科学十大进展”以及2019年度“中国生命科学十大进展”。

1. 2021年，北京市科技进步一等奖，排名9/15

2. 2022年，首届张丽珠生殖医学青年创新奖

1. 植入前胚胎谱系分化特征与细胞发育调控机制研究；国家科技部，国家重点研发计划，课题负责人；

2. 胚胎早期细胞命运决定的代谢调控及机制，国家重点研发计划专项，课题骨干；

3. 印记基因Gm13261在胚胎发育中的作用及机制探讨，国家自然科学基金委，课题负责人；

4. 基于生物正交光催化的卵母细胞发育过程中线粒体动态蛋白质组学研究，北京大学第三医院——交叉联合专项基金，课题负责人；

1. Lu Y#, Qin M#, He Q#, Hua L#, Qi X#, Yang M, Guo Q, Liu X, Zhang Z, Xu F, Ding L, Wu Y, Zhang C, Zhai F, Liu Q, Li J, Yuan P, Shi X, Wang X, Zhao C, Lian Y, Li R, Wei Y*, Yan L*, Yuan P*, Qiao J*. How the extra X chromosome impairs the development of male fetal germ cells. Nature. 2024 Nov;635(8040):960-968.

2. Zhou F#, Wang R#, Yuan P#, Ren Y#, Mao Y#, Li R, Lian Y, Li J, Wen L, Yan L, Qiao J*, Tang F*. Reconstituting the transcriptome and DNA methylome landscapes of human implantation. Nature. 2019 Aug;572(7771):660-664.

3. Guo Q#, Xu F#, Song S, Kong S, Zhai F, Xiu Y, Liu D, Li M, Lian Y, Ding L, Liu Q, Yang M, Du Z, Wang N, Long C, Wang X, Wang Y, Yan Z*, Qiao J*, Yan L*, Yuan P*. Allelic transcriptomic profiling identifies the role of PRD-like homeobox genes in human embryonic-cleavage-stage arrest. Developmental Cell. 2025 May 5;60(9):1290-1303.e6.

4. Lu Y#, Qin M#, Qi X#, Yang M, Zhai F, Zhang J, Yan Z, Yan L*, Qiao J*, Yuan P*. Sex differences in human pre-gastrulation embryos. Sci China Life Sci. 2025 Feb;68(2):397-415.

5. Wang Y#, Yuan P#, Yan Z#, Yang M#, Huo Y, Nie Y, Zhu X, Qiao J*, Yan L*. Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos. Nature Communications. 2021 Feb 23;12(1):1247.

6. Dang Y#, Zhu L#, Yuan P#, Liu Q#, Guo Q, Chen X, Gao S, Liu X, Ji S, Yuan Y, Lian Y, Li R, Yan L*, Wong CCL*, Qiao J*. Functional profiling of stage-specific proteome and translational transition across human pre-implantation embryo development at a single-cell resolution. Cell Discov. 2023 Jan 24;9(1):10.

7. Yuan P#, Guo Q#, Guo H, Lian Y, Zhai F, Yan Z, Long C, Zhu P, Tang F, Qiao J, Yan L*. The methylome of a human polar body reflects that of its sibling oocyte and its aberrance may indicate poor embryo development. Hum Reprod. 2021 Jan 25;36(2):318-330.

8. Yuan P#, Yang C#, Ren Y, Yan J, Nie Y, Yan L*, Qiao J. A novel homozygous mutation of phospholipase C zeta leading to defective human oocyte activation and fertilization failure. Hum Reprod. 2020 Apr 28;35(4):977-985.

9. Gao Y#, Li L#, Yuan P#, Zhai F#, Ren Y, Yan L, Li R, Lian Y, Zhu X, Wu X, Kee K, Wen L, Qiao J*, Tang F*. 5-Formylcytosine landscapes of human preimplantation embryos at single-cell resolution. PLoS Biol. 2020 Jul 30;18(7):e3000799.

10. Chen W#, Yuan P#, Yang M#, Yan Z, Kong S, Yan J, Liu X, Chen Y, Qiao J*, Yan L*. SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal-Fetal Interface. Engineering (Beijing). 2020 Oct;6(10):1162-1169.

11. He QL#, Yuan P#, Yang L, Yan ZQ, Chen W, Chen YD, Kong SM, Tang FC, Qiao J, Yan LY*. Single-cell RNA sequencing reveals abnormal fluctuations in human eight-cell embryos associated with blastocyst formation failure. Mol Hum Reprod. 2022 Jan 4;28(1):gaab069.

1. 发明专利，一种稳定获取体外输卵管腔液的冲洗装置及方法

2. 发明专利，一种同时原位荧光检测人类RNA、DNA、蛋白质的方法