王永清 北京大学第三医院妇产科主任医生，教授，博士生导师。目前在读博士/硕士研究生3人。长期专注于妊娠期高血压疾病发病机制的研究，针对子痫前期多因素、多机制、多通路的特点，从母胎界面炎症-免疫角度-内分泌角度，对子痫前期的病因和发病机制进行了深入研究。发现早发子痫前期病例类固醇激素分泌不平衡与SerpinF2及前凝血因子密切相关，完成miR-18a、miR-518b、miR-210等miRNA及其靶向调控与子痫前期发病机制研究；新近的研究发现，干扰素调节因子 1 介导的 Treg 细胞分化抑制诱导子痫前期母胎免疫失衡，研究结果发表在Pineal Research，MedComm 等杂志上。主持及承担国家自然科学基金及十三五、十四五国家重点研发计划子课题等多项课题，获得两项发明专利，发表SCI论文50多篇，参编专业书籍4部。

高级营养师，中华医学会医疗事故鉴定专家。《中国性科学》杂志副主编；《中国生育健康》杂志编委。全国卫生产业企业管理协会健康产业分会女性生育力保护学组委员；北京医学会中西医结合分会委员；北京医学会新生儿转运分会委员。中国医药健康协会母婴健康管理委员会常务委员。

获全国妇幼健康科技奖一等奖。

已经结题：血清松弛素在子痫前期发病中的作用及机制的研究。主持。国家自然科学基金(81450056)。

135项目国家重点研发计划《生殖健康及重大出生缺陷防控研究》课题八PI：妊娠因素对子代健康的影响和机制研究(2016YFC1000208)

目前承担：

145项目国家重点研发计划《胚胎源性疾病防治关键技术及体系建设研究 》课题四组长：婴幼儿肥胖代谢疾病的巢式病例对照研究和前瞻性研究（2022YFC2703504-4）

1. Shenglong Ye a,1, Xin Yu b,c,1, Wentong Jia b,c, Wenlong Li b,c, Yan-Ling Wang , Yongqing Wang^#. Hydroxychloroquine improves pregnancy outcomes by inhibiting excessive autophagy in extravillous trophoblast caused by an anti-phospholipid syndrome. International Immunopharmacology 157 (2025) 114749.

2. Liu J, Yang Y, Wu H, Dang F, Yu X, Wang F, Wang Y*, Wang YL.Hypoxia-induced O-GlcNAcylation of GATA3 leads to excessive testosterone production in preeclamptic placentas. MedComm. 2025 Feb 23;6(3):e70115.

3. Yangyang Zhang , Xunke Gu ,Nan Yang ,Yuting Xue ,Lijuan Ma , Yongqing Wang*, Hua Zhang and Keke Jia*.Prediction Models for Late-Onset Preeclampsia: A Study Based on Logistic Regression, Support Vector Machine, and Extreme Gradient Boosting Models.Biomedicines 2025,13,347.

4. Yue Ma, Shenglong Ye, Yuangying liu，Xueqing Zhao, Yanling Wang, Yongqing Wang* Interferon regulatory factor 1 mediated inhibition of Treg cell differentiation induces maternal-fetal immune imbalance in preeclampsia.International Immunopharmacology141(2024),

5. Yue Ma, Mingyue Ma, Shenglong Ye, Yuanying Liu, Xueqing Zhao, Yongqing Wang*. Risk factors for preeclampsia in patients with chronic kidney disease primarily focused on stage 1 CKD. Are referred and registered patients alike? Hypertension Research.15 May 2024.

6. Yeling Ma , Xin Yu , Shenglong Ye, Wenlong Li , Qian Yang e, Yu-xia Li , Yongqing Wang*, Yan-Ling Wang*. Immune-regulatory properties of endovascular extravillous trophoblast cells in human placenta. Placenta 145 (2024) 107–116.

7. Yue Ma, Mingyue Ma, Shenglong Ye, Yuanying Liu, Xueqing Zhao, Yongqing Wang.^# Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐ eclampsia: A systematic review and meta‐analysis. Immunity, inflammation and Disease. 26 September 2023.

8. Xuan Shao, Yun Yang, Yanlei Liu, Yongqing Wang,^# Yangyu Zhao, Xin Yu, Juan Liu, Yu-Xia Li, Yan-Ling Wang. Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta. Journal of Pineal Research, 25 September 2023.

9. Ye SL, Liu YY, Zhao XQ, Ma Y, Wang Y^#. Hydroxychloroquine improves pregnancy outcomes of pregnant women with positive antinuclear antibody spectrum test results [J]. Frontiers in Medicine.2023;10:1113127.

10. Ye S, Zhao X, Liu Y, Ma Y, Wang Y^#, Zhao J. The use of hydroxychloroquine in pregnancy and its effect on perinatal outcomes in a population with autoimmune abnormalities[J]. Clin Rheumatol. 2023;42(4):1137-1150.

11. Liu Y, Li R, Wang Y^#. Clinical outcomes and placental pathological characteristics after fresh embryo transfer and frozen-thawed embryo transfer with different endometrial preparation protocols[J]. Placenta. 2023;131:65-70.

12. Guanlin Li#, Yongqing Wang Y^#, Guangming Cao, Yeling Ma, Yu‑Xia Li, Yangyu Zhao, Xuan Shao and Yan‑Ling Wang.Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia.Journal of Biomedical Science (2022) 29:8.

13. Xu P#, Li Z#, Wang Y^#, Yu X, Shao X, Li YX, Peng C, Zhao Y*, Wang YL*. miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling. Mol Ther Nucleic Acids. 2020 Sep 23;22:542-556.

14. Wang H#, Zhao Y#, Luo R, Bian X, Wang Y^#, Shao X, Li YX, Liu M*, Wang YL*. A positive feedback self-regulatory loop between miR-210 and HIF-1αmediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsia. Biol Reprod. 2020, 102(3), 560–570.

15. Shao X^#, Wang Y^#, Liu Y^#, Guo X, Li D, Huo R, Jia W, Cao G, Li YX, Liu M, Sha J, Zhao Y, Wang YL*. Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia. J Hypertens. 2019 January 37.

一种子宫止血球囊，ZL 2013 2 0019215.9

用于婴幼儿期防控肥胖代谢疾病的血液光谱分析方法， ZL 2025 1 0073498.2