师资队伍

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徐慧玉

研究方向:
生殖内分泌与人工智能

招生专业:

地址:北京大学第三医院生殖医学中心生殖内分泌实验室

电话/传真:010-82265051

E-mail:huiyu56@bjmu.edu.cn

个人简介

徐慧玉,2011年北京大学生物化学与分子生物学专业博士毕业。北京大学第三医院生殖医学中心内分泌实验室负责人,亚太生殖大会(ASPIRE)AI专业组委员,北京慢病协会转化专委会副主任委员。从事性激素和大数据相关的临床应用研究,发表SCI论文40余篇,其中第一作者论文30余篇。申请或授权国家发明专利二十余项,申请PCT国际专利二十余项,其中多项国际国内专利实现了转化。获得2021年妇幼健康科技成果一等奖(3/15)、2019年教育部科技进步奖二等奖(5/15)、2021年北京大学产学研合作优秀项目奖等。作为主要研发成员之一的一系列发明专利已经转化应用,并写入了专家共识。其成果OvaRePred——全球首款卵巢储备评估和预测工具,入选The Innovation 2023全球十大科技进展,并授权美国公司探索美国市场。

社会兼职

The Innovation学术编辑

北京市慢病协会转化专委会副主任委员

北京保护健康协会第四届理事

中国初级卫生保健基金会数智健康管理与促进公益基金专委会委员

获奖情况

Ø 2024年医学装备协会转化医学分会 创新转化大赛二等奖

Ø 2023年2024年OvaRePred连续入选The Innovation全球科技焦点(The Innovation editorial team. Innovation focus in 2023. The Innovation 5(1), 100560)

Ø 2023年北京大学第三医院创新转化大赛二等奖

Ø 2022年北京大学第三医院创新转化大赛三等奖

Ø 2021年妇幼健康科技成果一等奖, 不孕症与辅助生殖中个体化评估与治疗应用研究(3/15)

Ø 2021年北京大学产学研合作优秀项目奖,利用大数据和人工智能评估卵巢储备功能

Ø 2020年Asian Journal of Andrology最佳论文奖

Ø 2020年北京大学第三医院第二届创新转化大赛三等奖

Ø 2019年教育部科技进步奖二等奖,提高辅助生殖技术治疗安全性及有效性策略研究(5/15),

Ø 2019年北京大学第三医院第二届创新转化大赛优秀奖

Ø 2018年北京大学第三医院首届创新转化大赛三等奖

Ø 2018年北京大学第三医院首届品管圈大赛三等奖

Ø 2017年北京大学第三医院技术创新三等奖

Ø 2017年北京大学第三医院优秀工会干部

承担项目

1. 主持十四五子课题项目一项。大课题名称:人群生育力受损早期识别和精准防控技术;课题一:我国青少年及育龄女性生育力受损情况及长期趋势演变 项目编号:2024YFC2706900

2. 主持十四五子课题项目一项。大课题名称:开发女性生殖健康管理智能化系统,建立防治一体化生殖健康大数据平台;课题一:建立中国育龄期女性生殖内分泌激素临床适用标准 项目编号:2023YFC2705500

3. 主持北医三院——康润创新转化基金项目一项,平台名称:北医三院—广州康润生殖与免疫项目联合研发中心,项目名称:生殖内分泌个体化医疗诊断技术研究,项目编号:CON20210900013

4. 主持2023北医三院创新转化基金,项目名称:POvaStim--全球首款个性化促排卵药物剂量指导工作,项目编号:BYSYZHKC2023102

5. 主持2021北医三院创新转化基金一项,项目名称:多囊卵巢综合征筛查模型的推广和应用,项目编号:BYSYZHKC2021104

6. 主持2020北医三院创新转化基金一项,项目名称:一种女性卵巢储备评估及预测的系统,项目编号:BYSYZHZB2020102

7. 参与国际规范化新药临床评价技术平台建设 国家科技重大专项, 编号:2017ZX09304012

8. 主持国家自然科学基金一项,编号:81300373

授权专利

1. 一种基于衍生化-液质联用技术定量检测生物样本中多种雄激素的方法,乔杰,李蓉,赵荣生,杨丽,张现化,徐慧玉,孙悦,刘灵灵,熊歆,赵立波。

2. 实用新型专利:一种多孔板的强力密封装置;发明人:张现化,徐慧玉,杨丽,赵荣生,李蓉,乔杰。专利号:202320310337.7;

3. 国家发明专利及PCT国际发明专利:预测卵巢多囊样改变(PCOM)的系统和方法;发明人:李蓉,徐慧玉,乔杰,赵荣生,杨丽,张现化,冯国双,韩勇,杨蕊,史莉,马聪聪。专利号:2023105187988,PCT/CN2023/094176;

4. 国家发明专利及PCT国际发明专利:预测月经周期延长的系统和方法;发明人:李蓉,徐慧玉,乔杰,赵荣生,杨丽,张现化,冯国双,韩勇,杨蕊,史莉,马聪聪。专利号:2023105194731,PCT/CN2023/094175;

5. 国家发明专利及PCT国际发明专利:激素检测数据的转换方法和系统;发明人:徐慧玉,李蓉,乔杰,冯国双,韩勇,史莉。申请号:202211676345.X; PCT/CN2022/XX;

6. 国家发明专利及PCT国际发明专利:一种筛查多囊卵巢综合征的系统和方法(三指标PCOS模型);发明人:徐慧玉,李蓉,乔杰,冯国双,韩勇。专利号:202211635867.5; PCT/CN2023/075024;

7. 国家发明专利及PCT国际发明专利:利用高效液相色谱-离子淌度差分质谱检测类固醇激素的方法。发明人:乔杰,李蓉,翟所迪,赵荣生,杨丽,徐慧玉,张现化,冯国双,韩勇,赵立波,熊歆。申请号:202211366715.X; PCT/CN2022/140976;

8. 国家发明专利及PCT国际发明专利:预测 COS 周期给予外源性卵泡刺激素药物剂量的系统及方法;发明人:徐慧玉,李蓉,乔杰,冯国双,韩勇。申请号:202210886125.3; PCT/CN2022/111753;

9. 国家发明专利及PCT国际发明专利:一种用于预测受试者的卵巢高反应的系统;发明人:徐慧玉、李蓉、乔杰、冯国双、韩勇。申请号:202210150332.2; PCT/CN2022/113035;

10. 国家发明专利及PCT国际发明专利:预测痴呆症或轻度认知障碍的系统和方法;发明人:韩勇、冯国双、徐慧玉、张洪宪、张丽;申请号:202210510090.3;PCT/CN2022/093822

11. 国家发明专利及PCT国际发明专利:优化的预测受试者卵巢刺激过程中获得的卵母细胞数量的系统;发明人:李蓉、徐慧玉、乔杰、冯国双、韩勇。申请号:202111509608.3; PCT/CN2022/078998;

12. 国家发明专利及PCT国际发明专利:用于评估受试者卵巢储备功能的系统(AA模型);发明人:徐慧玉、李蓉,乔杰、冯国双、韩勇。申请号:202110438776.1, PCT/CN2021/093551。

13. 国家发明专利及PCT国际发明专利:一种诊断多囊卵巢综合征的系统和方法(四指标PCOS模型);发明人:李蓉,徐慧玉、乔杰、冯国双、韩勇、史莉。专利号:ZL202110574591.3, PCT/CN2021/097896; 已授权、未转让;

14. 国家发明专利和PCT国际发明专利(三指标卵巢储备):优化的评估受试者卵巢储备功能的系统;发明人:乔杰,徐慧玉,李蓉,冯国双,韩勇。专利号:ZL 202010265214.7, PCT/CN2020/084465;

15. 国家发明专利和PCT国际发明专利(基于四指标卵巢储备模型):预测受试者出现卵巢储备新变化年限的系统和方法;发明人:徐慧玉,李蓉,乔杰,冯国双,韩勇。专利号:ZL202010663497.0,PCT/CN2020/102088;

16. 国家发明专利和PCT国际发明专利(基于三指标卵巢储备模型):预测受试者出现卵巢储备新变化年限的系统和方法;发明人:徐慧玉,李蓉,乔杰,冯国双,韩勇。专利号:ZL202010663498.5,PCT/CN2020/102090;

17. 国家发明专利及PCT国际发明专利:一种用于检测异位妊娠的系统和方法;发明人:李蓉,徐慧玉,乔杰、冯国双、韩勇。专利号:ZL201910236294.0, PCT/CN2020/083265;

18. 国家发明专利和PCT国际发明专利:预测受试者卵巢刺激过程中获得的卵母细胞数量的系统;发明人:李蓉,徐慧玉,乔杰、冯国双、韩勇。专利号:201910780793.6;PCT/CN2020/087232

19. 国家发明专利:预测拮抗剂方案下受试者卵巢低反应概率的系统及指导促性腺激素起始用药剂量选择的系统;发明人:李蓉、徐慧玉、冯国双、韩勇、乔杰;专利号:201810566858.2

20. 国家发明专利:预测新鲜移植周期受试者持续妊娠的系统;发明人:李蓉、徐慧玉、乔杰,冯国双,韩勇,陈立雪,杨蕊,何艺磊;专利号:ZL201811210067.2;

21. 国家发明专利及PCT国际发明专利:评估受试者卵巢储备功能的系统(四指标);发明人:李蓉、徐慧玉、乔杰。专利号:ZL 2018 1 1516206.4, PCT/CN2018/124766,

22. 软件著作权:多囊卵巢综合征筛查系统V1.0;登记号2021SR1485879

23. 软件著作权:女性卵巢功能与青春度智能评估系统V1.0; 登记号2021SR0623193

24. 软件著作权:AMH转换软件V1.0;登记号2023SR0809405

25. 软件著作权:促排卵药FSH剂量指导软件(简称:POvaStim)V1.0;登记号11396575

26. 软件著作权:卵巢反应预测计算工具软件V1.0;登记号11174719

发表论文情况

1. Huiyu Xu, Guoshuang Feng, Rui Yang, Rong Li,* and Jie Qiao*. Reaffirming the role of ovarian reserve in fertility assessment: Insights from OvaRePred. 2025 The Innovation Medicine 3(2):100135

2. Xianhua Zhang1, Huiyu Xu1, Yue Sun1, Xin Xiong1, Lingling Liu, Li Yang, Libo Zhao, Xiaona Li, Rong Li* Rongsheng Zhao* Simultaneous profiling of classic and 11-oxygenated androgens via a novel derivatization method coupled with HPLC-MS/MS: A game-changer for endocrine disorders.2025 Talanta Open 11:100459

3. Guoshuang Feng, Huiyu Xu, Shibiao Wan, Haitao Wang, Xiaofei Chen, Robert Magari, Yong Han, Yongyue Wei, and Hongqiu Gu. Twelve practical recommendations for developing and applying clinical predictive models 2024 The Innovation Medicine 2(4): 100105

4. Mingkun Tong, Hong Lu, Huiyu Xu, Xinguang Fan, Junfeng (Jim) Zhang, Frank J. Kelly, Jicheng Gong, Yiqun Han, Pengfei Li, Ruohan Wang, Jiajianghui Li, Tong Zhu, Tao Xue. Reduced human fecundity attributable to ambient fine particles in low- and middle-income countries. 2024 Environment International. 189 108784 IF=11.8

5. Huiyu Xu (徐慧玉), Wei Wang, Yong Han, Rong Li, and Jie Qiao. OvaRePred: Redefing ovarian aging and pioneering the journey towards women's health management. 2024 The Innovation Medicine 2(2): 100068

6. Guoshuang Feng, Juan Xia, Xinyu Wang, Hui Xu, Chanjuan Hao, Xin Zhang, Jinlei Qi, Peng Yin, Huiyu Xu, Yayuan Mei, and Maigeng Zhou Assessing the disease burden of air pollution on children and adolescents in China from 1990 to 2019. 2024 The Innovation Medicine 2(1): 100057

7. Huiyu Xu (徐慧玉). The Innovation Conference for Medicine: Fostering Collaborative Solutions through Thought-Provoking Questions. The Innovation Medicine 2023 1(3): 100044

8. 姚永玲,徐慧玉,张轩烨。北京大学第三医院:乔杰/李蓉教授团队最新研究揭秘卵巢衰老规律 中华医学信息导报 2023;38(19) :10

9. Mingkun Tong, Huiyu Xu (徐慧玉), Ruohan Wang, Hengyi Liu, Li L, Li P, Qiu X, Gong J, Shang J, Zhu T, Xue T. Estimating birthweight reduction attributable to maternal ozone exposure in low- and middle-income countries. 2023 Sci Adv. 2023 Dec 8; 9(49): eadh4363. IF=13.6

10. Huang T, Huiyu Xu (co-first 徐慧玉) , Haitao Wang, Yongjun Xu, Baohua Li, Shenda Hong, Guoshuang Feng, Shuyi Kui, Guangjian Liu, Dehua Jiang, Zhicheng Li, Ye Li, Congcong Ma, Chunyan Su, Wei Wang, Rong Li, Puxiang Lai, Jie Qiao. (2023) Artificial intelligence for medicine: Progress, challenges, and perspectives The Innovation Medicine 1(2): 100030

11. Congcong Ma, Huiyu Xu (co-first 徐慧玉), Xianhua Zhang, Guoshuang Feng, Li Shi, Yuan Su, Li Yang, Rongsheng Zhao, and Jie Qiao. (2023) Association of classic and 11-oxygenated androgens with polycystic ovaries and menstrual cycle prolongation in infertile women with PCOS. Clin Chim Acta, 547:117440 https://doi.org/10.1016/j.cca.2023.117440 IF=5.0

12. Huiyu Xu (徐慧玉), Guoshuang Feng, Rui Yang, Rong Li, Jie Qiao. (2023) OvaRePred: Online tool for predicting the age of fertility milestones. The Innovation 2023 4(5): 100490 IF=33.1

13. Huiyu Xu (徐慧玉), Guoshuang Feng, Rong Li, Ping Gao, and Jie Qiao. (2023) ADpred: A non-invasive model for three different types of dementia, and mild cognitive impairment. The Innovation Medicine 2023 1(2): 100026

14. Huiyu Xu (徐慧玉), Xianhua Zhang, Rui Yang, Guoshuang Feng, Li Yang, Rong Li. Can androgens be replaced by AMH in initial screening of Polycystic Ovary Syndrome? The Innovation Medicine 1(1): 100010

15. 李蓉,徐慧玉,金丽,赵涵,徐艳文,杨东梓,陈慧,周平,杨蕊,孔祥斌,巩纯秀,欧湘红,周灿权,乔杰 抗米勒管激素临床应用专家共识(2023年版)中国实用妇科与产科杂志 39:4 431-439

16. Huiyu Xu (徐慧玉), Guoshuang Feng*, Yong Han*, Antonio La Marca, Rong Li, and Jie Qiao. POvaStim: An online tool for directing individualized FSH doses in ovarian stimulation. The Innovation 2023 4(2): 100401 IF=33.1

17. Huiyu Xu (徐慧玉), Guoshuang Feng*, Li Shi*, Yong Han, Qin Huang, and Rong Li. PCOSt: A non-invasive and cost-effective screening tool for polycystic ovary syndrome. The Innovation 2023 4(2):100407 IF=33.1

18. Congcong Ma*, Huiyu Xu*†(co-first and co-corrependence (徐慧玉), Haiyan Wang, Guoshuang Feng, Yong Han, Kannan Alpadi, Jie Qiao†. An online tool for predicting ovarian responses in unselected patients using dynamic inhibin B and basal antimüllerian hormone levels. Frontiers in endocrinology 2023 14:1074347 IF=5.2

19. Huiyu Xu (徐慧玉), Guoshuang Feng*, Congcong Ma*, Yong Han, Jiansuo Zhou, Liyan Cui, Jiatian Song, Yuan Su, Qun Zhong, Fenghua Chen, and Rong Li. AMHconverter: an online tool for converting results between the different anti-Müllerian hormone assays of Roche Elecsys®, Beckman Access, and Kangrun. Peer J 2023 11:e15301 IF=2.8

20. Xianhua Zhang*, Huiyu Xu (co-first 徐慧玉), Guoshuang Feng, Li Yang, Libo Zhao, Rong Li, Rongsheng Zhao. Sensitive HPLC-DMS/MS/MS method coupled with dispersive magnetic solid phase extraction followed by in situ derivatization for the simultaneous determination of multiplexing androgens and 17-hydroxyprogesterone in human serum and its application to patients with polycystic ovarian syndrome. Clinica Chimica Acta 2022 538:221-230 https://doi.org/10.1016/j.cca.2022.11.025 IF=6.314

21. Yong Han*, Huiyu Xu (co-first 徐慧玉), Guoshuang Feng, Rong Li. An online tool using basal or activated ovarian reserve markers to predict the number of oocytes retrieved following controlled ovarian stimulation: a prospective observational cohort study. Frontiers in endocrinology 2022 13:881983 DOI: 10.3389/fendo.2022.881983 IF=6.055

22. Huiyu Xu(徐慧玉), Guoshuang Feng*, Kannan Alpadi, Yong Han, Lixue Chen, Rong Li, and Jie Qiao. A model for predicting polycystic ovary syndrome using serum anti-Müllerian hormone and androstenedione levels, menstrual cycle length and body mass index: a retrospective cohort study. Frontiers in endocrinology 2022 13:821368 DOI: 10.3389/fendo.2022.821368 IF=6.055

23. Yong Han*, Huiyu Xu (co-first 徐慧玉), Guoshuang Feng*, Haiyan Wang, Yong Han, Kannan Alpadi, Lixue Chen, Mengqian Zhang, Rong Li, and Jie Qiao. An online tool for predicting ovarian reserve based on AMH level and age: A retrospective cohort study. Frontiers in endocrinology 2022. 13:946123 IF=6.055

24. Xianhua Zhang*, Huiyu Xu (co-first 徐慧玉), Congya Zhou, Li Yang, Suodi Zhai, Ping Yang, Rongsheng Zhao, Rong Li. Magnetic solid phase extraction followed by in-situ derivatization with core-shell structured magnetic graphene oxide nanocomposite for the accurate quantification of free testosterone and free androstenedione in human serum. Journal of Chromatography B 2022 https://doi.org/10.1016/j.jchromb.2022.123188 IF=3.205

25. Pai Zheng, Zhangjian Chen, Jiaqi Chen, Yuting Xue, Yu Bai, Yulin Kang, Huiyu Xu, Guang Jia, Tiancheng Wang. Association between ambient air pollution and blood sex hormones levels in men. Environmental Research 2022 211:113117. IF=6.498

26. Huiyu Xu*, Shuo Yang*, Liyan Cui*, Guoshuang Feng, Rong Li, and Jie Qiao. Investigation on the risk factors for late-onset OHSS: A retrospective case-control study. Archives of Gynecology and Obstetrics. 2021 305(3):731-736 IF=2.493

27. Xianhua Zhang, Congya Zhou, Huiyu Xu, Ying Feng, Ping Yang, Suodi Zhai, Jiatian Song, Li Yang. A sensitive HPLC-DMS/MS/MS method for multiplex analysis of androgens in human serum without derivatization and its application to PCOS patients. Journal of Pharmaceutical and Biomedical Analysis 2022 192(5):113680 IF=3.571

28. Yongjun Xu, Xin Liu, Xin Cao, Changping Huang, Enke Liu, Sen Qian, Xingchen Liu, Yanjun Wu, Fengliang Dong, Chengwei Qiu, Junjun Qiu, Keqin Hua, Wentao Su, Jian Wu, Huiyu Xu, Yong Han, Chengquang Fu, Zhigang Yin, Miao Liu, Ronald Roepman, Sabine Dietmann, Marko Virta, Fredrick Kengara, Ze Zhang, Lifu Zhang, Taolan Zhao, Ji Dai, Jialiang Yang, Liang Lan, Ming Luo, Zhaofeng Liu, Tao An, Bin Zhang, Xiao He, Shan Cong, Xiaohong Liu, Wei Zhang, James P. Lewis, James M. Tiedje, Qi Wang, Zhulin An, Fei Wang, Libo Zhang, Tao Huang, Chuan Lu, Zhipeng Cai, Fang Wang, and Jiabao Zhang. Artificial Intelligence: A Powerful Paradigm for Scientific Research. The Innovation 2021 2:100179.

29. Huiyu Xu*, Mengqian Zhang*, Hongxian Zhang*, Kannan Alpadi, Lina Wang, Rong Li, Jie Qiao. Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update. The Innovation 2021 2:100091.

30. Kailun Hu, Fenting Liu, Huiyu Xu, Rong Li, Jie Qiao. High antimüllerian hormone levels are associated with preterm delivery in patients with polycystic ovary syndrome. Fertility and Sterility. 2020 113:444-452 IF=6.692

31. Huiyu Xu*, Li Shi*, Guoshuang Feng*, Zhen Xiao, Lixue Chen, Rong Li, Jie Qiao. An Ovarian Reserve Assessment Model Based on Anti-Mullerian Hormone Levels, Follicle-Stimulating Hormone Levels, and Age: Retrospective Cohort Study. JMIR 2020 22; e19096 IF=5.428

32. Yilu Chen, Defeng Liu, Lin Zeng, Huiyu Xu, Hui Jiang, Rui Yang, Haining Wang, Liying Yan, Rong Li, Jie Qiao, Xu Zhi. Effect of serum 25‐hydroxyvitamin D levels on sperm quality and assisted reproductive technology outcomes for men of infertile Chinese couples. Andrology 2020 8: 1277-1286. IF=3.842

33. Huiyu Xu*, Guoshuang Feng*, Haiyan Wang*, Yong Han, Rui Yang, Ying Song, Lixue Chen, Li Shi, Mengqian Zhang, Rong Li, Jie Qiao. A novel mathematical model of true ovarian reserve assessment based on predicted probability of poor ovarian response: a retrospective cohort study. Journal of assisted Reproduction and Genetics 2020 37:963-972. IF=3.412

34. Huiyu Xu*, Yuan Wei, Guoshuang Feng, Ying Feng, Rui Yang, Liying Wang, Hongxia Zhang, Rong Liv, and Jie Qiao. Predicting ectopic pregnancy using human chorionic gonadotropin (hCG) levels and main cause of infertility in women undergoing assisted reproductive treatment: Retrospective observational cohort study. JMIR medical Informatics 2020 8:e17366. IF=2.955

35. Huiyu Xu*, Hui Jiang*, Guoshuang Feng, Ying Feng, Yong Han, Wenhao Tang, Hongxian Zhang, Fenghua Chen, Rong Li, Jie Qiao. Establishing the lower limits of total serum testosterone among Chinese proven fertile men who received treatment of assisted reproductive technology. Asian J Androl. 2020;22:396. IF=3.285

36. Huiyu Xu, Hongxian Zhang,Zhen Xiao,Jie Qiao, and Rong Li. Regulation of AMH in males and the associations of serum AMH with the disorders of male fertility. Asian journal of Andrology 2019; 21:109-114. IF=2.448

37. Huiyu Xu, Yuan Wei, Rui Yang, Guoshuang Feng, Wenhao Tang, Hongxia Zhang, Yilei He, Ying Feng, Rong Li, Jie Qiao. Prospective observational cohort study: computational models for early prediction of ongoing pregnancy in fresh IVF/ICSI-ET protocols. Life Science 2019; 222: 221-227. IF=3.234

38. Jiamin Peng, Huiyu Xu (co-first), Yuan Chen, Wei Wang, Lifen Zhu, Yanfei Shao, Jianchao Wang. Screening for therapeutic targets of tumor angiogenesis signatures in 31 cancer types and potential insights. Biochemical and Biophysical Research Communications 2019; 508: 465-471 IF=2.559

39. Kailun Hu, Yongli Zhang, Zi Yang, Hongcui Zhao, Huiyu Xu, Yang Yu, Rong Li. Predictive value of serum kisspeptin concentration at 14 and 21 days after frozen–thawed embryo transfer. Reproductive BioMedicine Online 2019; 39: 161-167 IF=2.967

40. Hu KL, Liu FT, Xu H, Li R, Qiao J. High anti-Müllerian hormone levels are associated with preterm delivery in patients with polycystic ovary syndrome. Fertil Steril 2019. IF=5.411

41. Huiyu Xu, Yong Han, Jiaying, Hongxian Zhang, Yue Zhao, Balázs Győrffy, and Rong Li. PDGFRA, HSD17B4 and HMGB2 are potential therapeutic targets in polycystic ovarian syndrome and breast cancer. Oncotarget 2017; 8; 520-526 IF=5.168

42. 徐慧玉, 冯瑛, 曾琳, 乔杰, 李蓉。育龄女性月经周期内及周期间血清抗苗勒管激素水平的变化研究。实用妇产科杂志 2017; 33:358-362

43. Huiyu Xu, Lin Zeng, Rui Yang, Ying Feng, Rong Li*, and Jie Qiao*. Retrospective cohort study: AMH is the best ovarian reserve marker in predicting ovarian response but has unfavorable value in predicting clinical pregnancy in GnRHAntagonist protocol. Archives of Gynecology and Obstetrics 2017; 295:763-770 IF=2.09

44. Huiyu Xu, Yong Han, Bing Liu, Rong Li. Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10). Sci Rep 2016; 6:38508 IF=5.228

45. Huiyu Xu, Rong Li, and Jie Qiao. Homeodomain interacting protein kinase 2 is downregulated through the peroxisome proliferator-activated receptor gamma signaling pathway in an insulin-resistant population. J Diabetes Invest 2015; 6: 594-6. IF=1.825

46. Huiyu Xu, Bing Liu. CPEB4 is a candidate biomarker for defining metastatic cancers and directing personalized therapies. Medical Hypotheses 2013 Nov;81(5):875-7. IF=1.054

47. Li Min, Huiyu Xu, Juan Wang, Like Qu, Beihai Jiang, Yan Zeng, Lin Meng, H Jin, Chengchao Shou. N-a-acetyltransferase 10 is a negative regulator of 28S proteasome through interaction with PA28. FEBS Letters 2013; 587:1630-7. IF=3.538

48. Huiyu Xu, Beihai Jiang, Lin Meng, Tingting Ren,Yan Zeng, Jian Wu, Like Qu, Chengchao Shou. N-alpha-Acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression. Carcinogenesis 2012; 33:1193-1202. IF=5.702

49. Zhao Y, Zhou J, Liu D, Dong F, Cheng H, Wang W, Pang Y, Wang Y, Mu X, Ni Y, Li Z, Xu H, Hao S, Wang X, Ma S, Wang QF, Xiao G, Yuan W, Liu B, Cheng T. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood 2015 126:2383-91 IF=10.452

50. Zeng Y, Min L, Han Y, Meng L, Liu C, Xie Y, Dong B, Wang L, Jiang B, Xu H, Zhuang Q, Zhao C, Qu L, Shou C. Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis. Carcinogenesis 2014; 35:2244-53. IF=5.334

51. Tingting Ren, Beihai Jiang, Xiaofang Xing, Bin Dong, Lirong Peng, Lin Meng, Huiyu Xu, Chengchao Shou. Prognostic significance of phosphatase of regenerating liver-3 expression in ovarian cancer. Pathol Oncol Res 2009; 15:555-560. IF=1.15

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