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杭婧

研究员/副教授/博士生导师

研究方向:
生殖代谢稳态与蛋白功能调控

招生专业:妇产科学;生殖科学;生物化学与分子生物学

地址:北医三院生殖医学中心B4015

电话/传真:

E-mail:hangjbysy@bjmu.edu.cn

个人简介

杭婧,北京大学第三医院生殖医学中心研究员/副教授,博士生导师,荣获北京市科技新星、北京医学科技二等奖、北大医学青年科技奖、张丽珠生殖医学创新奖一等奖等。主要运用结构生物学、生殖生物学等交叉研究手段,研究生殖发育与妊娠疾病中代谢调控相关蛋白质的结构基础与分子作用机制。共发表SCI和核心期刊论文30篇;包括以通讯或第一(含共同)作者发表的ScienceCellCell Discov.Sci Adv等论文23篇,累计总引1000余次。研究成果分别入选中国生命科学十大进展与中国科学十大进展。作为负责人主持并参与科技部国家重点研发计划课题、国家自然科学基金面上/青年项目、北京市科委项目等科研课题共9项。担任中国生理学会生殖科学专委会、中国女医师协会母胎医学专委会委员等。申请/授权国家发明专利2项,参编英文专著一部。


教育与工作经历

2024.01~至今 北京大学第三医院 生殖医学中心 研究员/副教授

2017.08~2023.12 北京大学第三医院 生殖医学中心 副研究员/助理教授

2012.09~2017.06 清华大学 医学院 生物学 博士

2008.09~2012.06 武汉大学 生命科学学院 生命科学与技术 学士




代表性论文

1. Yi, H.#, Liang, W.#, Yang, S., Liu, H., Deng, J., Han, S., Feng, X., Cheng, W., Chen, Y., Hang, J.*, Lu, H.*, & Ran, R.* (2025). Melanin deposition and key molecular features in Xenopus tropicalis oocytes. BMC biology, 23(1), 62.

2. Ran R#*, Li L#, Cheng P., Li H., He H., Chen, Y*, Hang, J*, Liang, W*. High frequency of melanoma in cdkn2b-/-/tp53-/- Xenopus tropicalis. Theranostics. 2024; 14 (19): 7470-7487

3. Wang, X.#, Zhou, S.#, Hu X.#, Ye C., Nie, Q., Wang, K., Yan, S., Lin, J., Xu, F., Li, M., Wu, Q., Sun, L., Liu, B., Zhang, Y., Yun, C., Wang, X., Liu, H., Yin, W., Zhao, D., Hang, J.*, Zhang, S.*, Jiang, C.*, Pang, Y.* (2024). Candida albicans accelerates atherosclerosis by activating intestinal hypoxia-inducible factor-2α signaling, Cell Host & Microbe, 32(6), 964–979.e7. 4.

4. Chen, C.#, Wen, Q.#, Deng, F., Li, R., Wang, Y., Zhen, X. *, & Hang, J. * (2024). Endometrial protein expression and phosphorylation landscape decipher aberrant insulin and mTOR signaling in patients with recurrent pregnancy loss. Reprod Biomed Online, 48(1):103585

5. Jin, Z.#, Cao, Y.#, Wen, Q.#, Zhang, H., Fang, Z., Zhao, Q., Xi, Y., Luo, Z., Jiang, H.*, Zhang, Z.*, & Hang, J.* (2024). Dapagliflozin ameliorates diabetes-induced spermatogenic dysfunction by modulating the adenosine metabolism along the gut microbiota-testis axis. Sci Rep, 14(1), 641.

6. Wang, K.#, Zhang, Z.#, Hang, J.#, Liu, J.#, Guo, F.#, Ding, Y., Li, M., Nie, Q., Lin, J., Zhuo, Y., Sun, L., Luo, X., Zhong, Q., Ye, C., Yun, C., Zhang, Y., Wang, J., Bao, R., Pang, Y., Wang, G.*, Gonzalez, F.*, Lei, X.*, Qiao, J.*, Jiang, C.* (2023). Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. Science, 381(6657), eadd5787.

7. Zhao, C.#, You, Z.#, Chen, D.#, Hang, J.#,*, Wang, Z., Peng Zhao, P., Qiao, J.*, Yun, C.,*,& Bai, L.*(2023). Structure of a fungal 1,3-β-glucan synthase. Sci Adv, 9(37), eadh7820.

8. Jin, Z.#, Yang, Y.#, Cao, Y.#, Wen, Q., Xi, Y., Cheng, J., Zhao, Q., Weng, J., Hong, K., Jiang, H.*, Hang, J.*, Zhang, Z.* (2023). The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis. Microbiome, 11(1), 212. 7.

9. Zhong, Q.#, Chu, H.#, Wang, G.#, Zhang, C.#, Li, R., Guo, F., Meng, X., Lei, X., Zhou, Y., Ren, R., Tao, L., Li, N., Gao, N., Wei, Y.*, Qiao, J.*, & Hang, J.* (2022). Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2. Cell Discov 8(1), 137.

10. Hang, J.#, Wang, J.#, Lu, M., Xue, Y., Qiao, J.*, & Tao, L.* (2022). Protein O-mannosylation across kingdoms and related diseases: From glycobiology to glycopathology. Biomed & pharmacother, 148, 112685.

11. Zhong, Q.#, Lu, M.#, Yuan, W.#, Cui, Y., Ouyang, H., Fan, Y., Wang, Z., Wu, C.*, Qiao, J.*, & Hang, J.* (2021). Eight-lncRNA signature of cervical cancer were identified by integrating DNA methylation, copy number variation and transcriptome data. J Transl Med, 19(1), 58.

12. Hou, E., Zhao, Y., Hang, J.*, & Qiao, J.* (2021). Metabolomics and correlation network analysis of follicular fluid reveals associations between l-tryptophan, l-tyrosine and polycystic ovary syndrome. Biomed chromatogr, 35(3), e4993.

13. Li, J.#, Lu, M.#, Zhang, P.#, Hou, E., Li, T., Liu, X., Xu, X., Wang, Z., Fan, Y., Zhen, X., Li, R., Liu, P., Yu, Y., Hang, J.*, & Qiao, J. (2020). Aberrant spliceosome expression and altered alternative splicing events correlate with maturation deficiency in human oocytes. Cell cycle, 19(17), 2182–2194.

14. Zhang, X.#, Yan, C.#, Hang, J.#, Finci, L. I., Lei, J., & Shi, Y.* (2017). An Atomic Structure of the Human Spliceosome. Cell, 169(5), 918–929.

15. Hang, J.#, Wan, R.#, Yan, C.#, & Shi, Y.* (2015). Structural basis of pre-mRNA splicing. Science, 349(6253), 1191–1198.

16. Yan, C.#, Hang, J.#, Wan, R.#, Huang, M., Wong, C. C., & Shi, Y.* (2015). Structure of a yeast spliceosome at 3.6-angstrom resolution. Science, 349(6253), 1182–1191.

17. Zhou, L.#, Hang, J.#, Zhou, Y., Wan, R., Lu, G., Yin, P., Yan, C., & Shi, Y.* (2014). Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature, 506(7486), 116–120.

承担课题

1. 国家自然科学基金面上项目,2025.01-2028.12,主持,在研

2. 北京大学临床医学+X青年专项,2025.01-2025.12,主持,在研

3. 国家重点研发计划重点专项,2022.12-2025.11,主持,在研

4. 国家自然科学基金面上项目,2021.01-2024.12,主持,结题

5. 国家自然科学基金青年项目,2019.01-2021.12,主持,结题

6. 北京市科技新星交叉课题,2022.12-2024.11,主持,结题

7. 北京市科技新星计划,2020.09-2023.08,主持,结题

8. 北京大学第三医院重点人才项目,2024.01-2026.12,主持,在研

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